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Paxil is also used to treat major depression, anxiety, generalized anxiety disorder or gad, and panic disorder.

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The efficacy of paxil was established in two 12-week trials with obsessive compulsive outpatients whose diagnoses corresponded most closely to the dsm-iiir category of obsessive compulsive disorder see clinical trials .

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The antidepressive activity of paxil is conditioned by the specific selective serotonin reuptake inhibition in the neurons of the brain.

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Voluntary reports of adverse events in patients taking paxil that have been received since market introduction and not listed above that may have no causal relationship with the drug include acute pancreatitis, elevated liver function tests the most severe cases were deaths due to liver necrosis, and grossly elevated transaminases associated with severe liver dysfunction , guillain barr syndrome, stevens-johnson syndrome, toxic epidermal necrolysis, priapism, syndrome of inappropriate adh secretion, symptoms suggestive of prolactinemia and galactorrhea; extrapyramidal symptoms which have included akathisia, bradykinesia, cogwheel rigidity, dystonia, hypertonia, oculogyric crisis which has been associated with concomitant use of pimozide; tremor and trismus; status epilepticus, acute renal failure, pulmonary hypertension, allergic alveolitis, anaphylaxis, eclampsia, laryngismus, optic neuritis, porphyria, restless legs syndrome rls , ventricular fibrillation, ventricular tachycardia including torsade de pointes , thrombocytopenia, hemolytic anemia, events related to impaired hematopoiesis including aplastic anemia, pancytopenia, bone marrow aplasia, and agranulocytosis , vasculitic syndromes such as henoch-sch nlein purpura , and premature births in pregnant women.

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there are currently five ssris available in the united states prozac fluoxetine , zoloft sertraline , paxil paroxetine , luvox fluvoxamine , and celexa citalopram .

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